Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.66 |
| ▸ | MMP2 | P08253 | 13/20 | 0.45 |
| ▸ | MMP1 | P03956 | 10/20 | 0.45 |
| ▸ | MMP8 | P22894 | 5/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 11/20 | 0.40 |
| ▸ | MMP7 | P09237 | 7/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938052 | 1.00 | ADAM17 (0.66) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6945863 | 0.89 | ADAM17 (0.55) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6945579 | 0.84 | ADAM17 (0.62) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6940043 | 0.83 | ADAM17 (0.48) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6943815 | 0.80 | ADAM17 (0.62) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL13274076 | 0.79 | ADAM17 (1.00) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6813844 | 0.79 | ADAM17 (1.00) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL4481744 | 0.79 | ADAM17 (1.00) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6813847 | 0.79 | ADAM17 (1.00) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL3500092 | 0.79 | ADAM17 (1.00) | ADAM17MMP2MMP1MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |