Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20382633 | 0.95 | NPC1 (0.78) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL19043207 | 0.90 | NPC1 (0.74) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL9657455 | 0.85 | NPC1 (0.83) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL19043463 | 0.85 | NPC1 (0.83) | NPC1L3MBTL1MMP1 | |
| SCHEMBL7923674 | 0.83 | NPC1 (0.81) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL3032173 | 0.83 | NPC1 (0.81) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL11825763 | 0.83 | NPC1 (0.81) | NPC1L3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL11263173 | 0.83 | NPC1 (0.81) | NPC1L3MBTL1 | |
| SCHEMBL14960046 | 0.83 | PDE4B (0.75) | NPC1L3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL7923393 | 0.83 | L3MBTL1 (0.79) | NPC1L3MBTL1ALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |