Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.90 |
| ▸ | EGFR | P00533 | 12/20 | 0.90 |
| ▸ | ABL1 | P00519 | 12/20 | 0.90 |
| ▸ | ABL2 | P42684 | 11/20 | 0.90 |
| ▸ | LCK | P06239 | 6/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.67 |
| ▸ | KIF5B | P33176 | 3/20 | 0.67 |
| ▸ | IGF1R | P08069 | 3/20 | 0.67 |
| ▸ | JAK2 | O60674 | 2/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.67 |
| ▸ | INSR | P06213 | 2/20 | 0.67 |
| ▸ | NPM1 | P06748 | 2/20 | 0.67 |
| ▸ | CSF1R | P07333 | 2/20 | 0.67 |
| ▸ | LYN | P07948 | 2/20 | 0.67 |
| ▸ | MET | P08581 | 2/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | KIT | P10721 | 2/20 | 0.67 |
| ▸ | BCR | P11274 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098846 | 0.91 | SRC (0.75) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8098919 | 0.90 | SRC (0.90) | SRCEGFRABL1ABL2 | |
| SCHEMBL8108104 | 0.90 | SRC (0.91) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8107053 | 0.89 | SRC (0.90) | SRCEGFRABL1ABL2RET | |
| SCHEMBL7020683 | 0.88 | SRC (0.74) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8112759 | 0.87 | SRC (0.73) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL28667953 | 0.87 | SRC (0.79) | SRCEGFRABL1ABL2 | |
| SCHEMBL8108111 | 0.85 | SRC (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8107030 | 0.85 | SRC (1.00) | SRCEGFRABL1ABL2 | |
| SCHEMBL13020336 | 0.85 | SRC (0.76) | SRCEGFRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |