Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636721 | 0.83 | HSD11B1 (0.44) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL12791827 | 0.83 | HSD11B1 (0.44) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL3218526 | 0.83 | HSD11B1 (0.41) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL3033655 | 0.81 | HSD11B1 (0.42) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL13081509 | 0.81 | HSD11B1 (0.44) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL8104917 | 0.79 | SCN9A (0.39) | HSD11B1 | |
| SCHEMBL12128673 | 0.78 | HSD11B1 (0.46) | HSD11B1HSD11B2 | |
| SCHEMBL1696544 | 0.77 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL13586952 | 0.77 | HSD11B1 (0.41) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL10087714 | 0.77 | HSD11B1 (0.40) | HSD11B1HSD11B2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5650406-A | ANTISCHIZOPHRENIC AGENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0757040-A1 | ADAMANTANE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1997-02-05 | — | — | EP | disclosed |
| EP-0661271-A1 | AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-07-05 | — | — | EP | disclosed |