Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389131 | 0.92 | DHFR (0.52) | DHFRRETALKFLT3PDPK1 | |
| SCHEMBL8099054 | 0.89 | PDPK1 (0.50) | PDPK1CHEK1HSP90AA1IDO1CHEK2 | |
| SCHEMBL8099047 | 0.87 | PLK4 (0.56) | RETRPS6KA3CHEK1HSP90AA1IDO1 | |
| SCHEMBL8099022 | 0.87 | FLT3 (0.53) | ALKFLT3RPS6KA3CHEK1HSP90AA1 | |
| SCHEMBL8348594 | 0.86 | KDM4E (0.52) | CHEK1HSP90AA1IDO1CHEK2CDK1 | |
| SCHEMBL8300100 | 0.85 | MAP3K7 (0.62) | RETALKFLT3RPS6KA3CHEK1 | |
| SCHEMBL7872417 | 0.85 | MAP3K7 (0.62) | RETALKFLT3RPS6KA3CHEK1 | |
| SCHEMBL8497904 | 0.82 | PAK1 (0.47) | PDPK1 | |
| SCHEMBL1389087 | 0.81 | PDPK1 (0.50) | PDPK1CHEK1CDK1MAP3K7TAB1 | |
| SCHEMBL8506386 | 0.80 | TLK2 (0.47) | PDPK1CHEK1CHEK2CDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658159-B1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2000-08-23 | — | — | EP | claimed |
| US-5905149-A | CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND | PHARMACIA & UPJOHN S.P.A (IT) | 1999-05-18 | — | — | US | disclosed |
| EP-0876365-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997046551-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-11 | — | — | WO | disclosed |