Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.57 |
| ▸ | MMP1 | P03956 | 3/20 | 0.57 |
| ▸ | MMP2 | P08253 | 3/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975479 | 0.88 | KMT2A (0.69) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL975477 | 0.88 | KMT2A (0.69) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL29060766 | 0.82 | HDAC2 (0.76) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL4029206 | 0.82 | HDAC2 (0.76) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL22645401 | 0.80 | ALDH1A1 (0.62) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL28440928 | 0.80 | HDAC2 (0.73) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL28440927 | 0.80 | HDAC2 (0.73) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL6971897 | 0.79 | TDP1 (0.65) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL6643474 | 0.79 | HDAC3 (0.66) | KMT2AHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL27283033 | 0.79 | HDAC3 (0.66) | KMT2AHDAC3HDAC1HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140341-A | FOR TREATING PAIN | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-10-31 | — | — | US | disclosed |
| EP-0795547-B1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AG (DE) | 2000-05-10 | — | — | EP | disclosed |
| EP-0795547-A1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-17 | — | — | EP | disclosed |