Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090241 | 0.95 | NAMPT (0.43) | NAMPTPIK3CDPIK3CAMTORROCK2 | |
| SCHEMBL8083986 | 0.92 | CA2 (0.39) | NAMPTPIK3CDPIK3CAMTORKDM4E | |
| SCHEMBL8090391 | 0.91 | CA1 (0.41) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8092289 | 0.91 | CA1 (0.41) | NAMPTPIK3CDPIK3CAMTORKDM4E | |
| SCHEMBL8083655 | 0.90 | NAMPT (0.43) | NAMPTPIK3CDPIK3CAKDR | |
| SCHEMBL8091160 | 0.89 | NAMPT (0.38) | NAMPTPIK3CDPIK3CAMTORKDM4E | |
| SCHEMBL8104820 | 0.89 | CA2 (0.38) | NAMPTPIK3CDPIK3CAMTORKDM4E | |
| SCHEMBL8083993 | 0.89 | CA2 (0.38) | NAMPTPIK3CDPIK3CAMTORKDM4E | |
| SCHEMBL8084990 | 0.87 | CA1 (0.40) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8091068 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CAMTORKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |