Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | TPMT | P51580 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | PPOX | P50336 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135845 | 0.89 | MAPT (0.56) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL8184777 | 0.83 | TPMT (0.62) | MAPTMEN1KMT2AHPGDTPMT | |
| SCHEMBL6725156 | 0.80 | MRGPRX4 (0.51) | MAPTMEN1KMT2ATPMTLMNA | |
| SCHEMBL28070439 | 0.78 | MEN1 (0.59) | MAPTMEN1KMT2AHPGDTPMT | |
| SCHEMBL1190543 | 0.77 | TPMT (0.70) | MAPTMEN1KMT2AHPGDTPMT | |
| SCHEMBL3137542 | 0.76 | HPGD (0.66) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL5220434 | 0.75 | TPMT (0.81) | MAPTMEN1KMT2AHPGDTPMT | |
| SCHEMBL11276396 | 0.75 | TDP1 (0.83) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL11109657 | 0.75 | AKR1C3 (0.49) | MAPTMEN1KMT2AHPGDLMNA | |
| SCHEMBL29493652 | 0.74 | TPMT (0.74) | MAPTMEN1KMT2AHPGDTPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954299-A4 | METHOD OF TREATING MALIGNANT TUMORS WITH THYROXINE ANALOGUES HAVING NO SIGNIFICANT HORMONAL ACTIVITY | OCTAMER INC (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-0954299-A1 | METHOD OF TREATING MALIGNANT TUMORS WITH THYROXINE ANALOGUES HAVING NO SIGNIFICANT HORMONAL ACTIVITY | Octamer, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1997046228-A1 | METHOD OF TREATING MALIGNANT TUMORS WITH THYROXINE ANALOGUES HAVING NO SIGNIFICANT HORMONAL ACTIVITY | OCTAMER, INC. (US) | 1997-12-11 | — | — | WO | disclosed |