Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100190 | 0.95 | SMN1; SMN2 (0.33) | GAACYP1A2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8337950 | 0.95 | GAA (0.35) | GAACYP1A2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8013343 | 0.90 | GAA (0.38) | GAACYP1A2LMNASMN1; SMN2GABRA2 | |
| SCHEMBL8099222 | 0.90 | GAA (0.38) | GAACYP1A2GABRA2GABRB2POLB | |
| SCHEMBL7820509 | 0.90 | GAA (0.34) | GAACYP1A2GABRA2GABRB2TP53 | |
| SCHEMBL7820269 | 0.87 | P2RY12 (0.37) | GAAKMT2AMEN1 | |
| SCHEMBL8013354 | 0.87 | GAA (0.36) | GAACYP1A2GABRA2GABRB2TP53 | |
| SCHEMBL7844105 | 0.84 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL8098047 | 0.84 | GAA (0.36) | GAACYP1A2LMNASMN1; SMN2GABRA2 | |
| SCHEMBL8011792 | 0.83 | GAA (0.36) | GAACYP1A2GABRA2GABRB2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |