Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100183 | 0.95 | GAA (0.36) | GAAGABRA2GABRB2CYP1A2SMN1; SMN2 | |
| SCHEMBL8100190 | 0.93 | SMN1; SMN2 (0.33) | GAAGABRA2GABRB2CYP1A2SMN1; SMN2 | |
| SCHEMBL7844105 | 0.90 | P2RX7 (0.34) | P2RX7KDM4E | |
| SCHEMBL8013343 | 0.87 | GAA (0.38) | GAAGABRA2GABRB2CYP1A2SMN1; SMN2 | |
| SCHEMBL7835755 | 0.85 | ALDH1A1 (0.36) | GAASMN1; SMN2LMNAP2RX7MAPT | |
| SCHEMBL8099222 | 0.85 | GAA (0.38) | GAAGABRA2GABRB2CYP1A2P2RX7 | |
| SCHEMBL7820509 | 0.85 | GAA (0.34) | GAAGABRA2GABRB2CYP1A2TP53 | |
| SCHEMBL7820269 | 0.84 | P2RY12 (0.37) | GAAMEN1KMT2A | |
| SCHEMBL8013354 | 0.82 | GAA (0.36) | GAAGABRA2GABRB2CYP1A2TP53 | |
| SCHEMBL8337317 | 0.81 | GAA (0.36) | GAAGABRA2GABRB2CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |