SCHEMBL8100604

SCHEMBL8100604

Cc1c(CCl)ccc(O[SiH3])c1C

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 1/20 0.35
TSHR P16473 1/20 0.35
KMT2A Q03164 1/20 0.35
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2103383 0.81 MEN1 (0.51) ALDH1A1MEN1TSHRKMT2ALMNA
SCHEMBL1019627 0.79 PON1 (0.35) ALDH1A1TSHRKMT2A
SCHEMBL11212134 0.73 AOC3 (0.42) ALDH1A1MEN1TSHRKMT2ALMNA
SCHEMBL1271763 0.73 PON1 (0.31)
SCHEMBL5665767 0.72 TUBB4A (0.33) ALDH1A1MEN1TSHRKMT2ALMNA
SCHEMBL1271713 0.71 PON1 (0.30)
SCHEMBL11421126 0.71 CES1 (0.34) ALDH1A1MEN1KMT2AMAPT
SCHEMBL633713 0.70 NCEH1 (0.33) MEN1TSHRKMT2A
SCHEMBL2495516 0.70 PON1 (0.43) TSHRKMT2A
Ammonia Solution, Strong SCHEMBL136349 0.69 PON1 (0.46) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700951-B1 Polyorganosiloxane and process for producing the same SHOWA DENKO KK (JP) 2000-12-27 EP disclosed
US-5622784-A WATERPROOFING; MODIFIED SILICON DIOXIDE THIN FILM SEIKO EPSON CORPORATION (JP) 1997-04-22 US disclosed
EP-0700951-A1 Polyorganosiloxane and process for producing the same SHOWA DENKO KABUSHIKI KAISHA (JP) 1996-03-13 EP disclosed
US-5491203-A COMPRISES POLYSILSESQUIOXANE STRUCTURE; HAS METHYL GROUP AND A REACTIVE GROUP ON SIDE CHAINS; SUITABLE AS POLYMER MODIFIER; CROSSLINKING; COATINGS SHOWA DENKO K. K. (JP) 1996-02-13 US disclosed
EP-0455269-B1 Packing for use in resolution DAICEL CHEM (JP) 1993-11-10 EP disclosed
EP-0455269-A1 Packing for use in resolution DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1991-11-06 EP disclosed
EP-0150221-B1 PACKING FOR USE IN SEPARATION DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1990-08-08 EP disclosed
EP-0318469-A1 Packing for use in resolution DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1989-05-31 EP disclosed
US-4627919-A Resolving agent DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1986-12-09 US disclosed
US-4619984-A MODIFIED SILICA GEL DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1986-10-28 US disclosed
EP-0150221-A1 PACKING FOR USE IN SEPARATION DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1985-08-07 EP disclosed