SCHEMBL8100657

SCHEMBL8100657

C#CCOc1cc(-n2nc(C3CC3)sc2=O)c(F)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPOX P50336 10/20 0.35
POLB P06746 1/20 0.33
PGK1 P00558 1/20 0.33
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8110127 0.92 PPOX (0.35) PPOXPOLBMAPT
SCHEMBL8109978 0.91 PPOX (0.37) PPOXPOLBPGK1MAPT
SCHEMBL8109993 0.89 PPOX (0.36) PPOXPOLB
SCHEMBL8101200 0.88 PPOX (0.35) PPOXPOLB
SCHEMBL8100821 0.88 PGK1 (0.35) PPOXPOLBPGK1MAPT
SCHEMBL8110702 0.84 PPOX (0.50) PPOXPOLB
SCHEMBL8110674 0.84 PPOX (0.35) PPOXPOLBMAPT
SCHEMBL8110417 0.82 PPOX (0.40) PPOXPOLB
SCHEMBL8110179 0.82 PPOX (0.38) PPOX
SCHEMBL8109232 0.82 PPOX (0.43) PPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0780385-B1 Arylthiadiazolones with a herbicidal activity ISAGRO RICERCA SRL (IT) 2000-05-10 EP claimed
US-5821197-A CYCLIZATION OF A THIOHYDRAZIDE ISAGRO RICERCA S.R.L. (IT) 1998-10-13 US claimed
EP-0780385-A1 Arylthiadiazolones with a herbicidal activity ISAGRO RICERCA S.r.l. (IT) 1997-06-25 EP claimed
EP-0780385-B1 Arylthiadiazolones with a herbicidal activity ISAGRO RICERCA SRL (IT) 2000-05-10 EP disclosed
US-5821197-A CYCLIZATION OF A THIOHYDRAZIDE ISAGRO RICERCA S.R.L. (IT) 1998-10-13 US disclosed
EP-0780385-A1 Arylthiadiazolones with a herbicidal activity ISAGRO RICERCA S.r.l. (IT) 1997-06-25 EP disclosed