Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CTSC | P53634 | 15/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288244 | 0.93 | CYP2C19 (0.70) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL43293 | 0.93 | CYP2C19 (0.70) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL43292 | 0.93 | CYP2C19 (0.70) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL7382497 | 0.92 | CYP2C19 (0.68) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL7382495 | 0.92 | CYP2C19 (0.68) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5236901 | 0.83 | CYP2C19 (0.57) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5236908 | 0.83 | CYP2C19 (0.57) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7252652 | 0.81 | CYP2C19 (0.54) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7252654 | 0.81 | CYP2C19 (0.54) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 | |
| Isoleucine SCHEMBL8483685 | 0.80 | CYP2C19 (0.53) | CYP2C19CTSCSLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973936-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998046786-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |