Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264482 | 0.80 | BRD3 (0.46) | TAAR1ACHEKDM4EHPGDALDH1A1 | |
| SCHEMBL31231879 | 0.78 | NPC1 (0.36) | ACHEALDH1A1CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL7325029 | 0.77 | SIRT1 (0.52) | ACHEKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL9732211 | 0.73 | KDM4E (0.35) | KDM4EHPGDALDH1A1CASP1HSD17B10 | |
| SCHEMBL23804839 | 0.73 | KDM4E (0.35) | KDM4EHPGDALDH1A1CASP1HSD17B10 | |
| SCHEMBL8115526 | 0.71 | SIRT1 (0.39) | TAAR1ACHEKDM4EHPGDALDH1A1 | |
| SCHEMBL13950958 | 0.70 | RAB9A (0.43) | TAAR1ACHEKDM4EGAASMN1; SMN2 | |
| SCHEMBL25290911 | 0.69 | CYP2D6 (0.48) | TAAR1KDM4EHPGDGAACYP2D6 | |
| SCHEMBL25290910 | 0.69 | CYP2D6 (0.48) | TAAR1KDM4EHPGDGAACYP2D6 | |
| SCHEMBL7481693 | 0.69 | CYP3A4 (0.52) | TAAR1KDM4EHPGDALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929299-A4 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS | LILLY CO ELI (US) | 2000-12-20 | — | — | EP | disclosed |
| CN-1228695-A | Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta [b] benzofurans | LILLY CO ELI (US) | 1999-09-15 | — | — | CN | disclosed |
| EP-0929299-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA(b)BENZOFURANS | ELI LILLY AND COMPANY (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998008502-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b]BENZOFURANS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |