Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737305 | 0.84 | HTR1A (0.55) | GAASLC6A4HTR1AHTR3ASLC6A2 | |
| SCHEMBL5607173 | 0.82 | ALDH1A1 (0.56) | ALDH1A1GAASLC6A4CYP3A4TDP1 | |
| SCHEMBL395415 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GAASLC6A4CYP3A4TDP1 | |
| SCHEMBL29597724 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GAASLC6A4CYP3A4TDP1 | |
| SCHEMBL31666386 | 0.82 | HTR1A (0.50) | ALDH1A1GAAHTR1AHTR3ACYP3A4 | |
| SCHEMBL4950654 | 0.82 | HTR1A (0.50) | ALDH1A1GAAHTR1AHTR3ACYP3A4 | |
| SCHEMBL9292115 | 0.81 | ALDH1A1 (0.47) | ALDH1A1GAASLC6A4TDP1ADRA2B | |
| SCHEMBL8659962 | 0.81 | IDO1 (0.53) | ALDH1A1GAASLC6A4HTR1AHTR3A | |
| Hydrochloric Acid SCHEMBL10423028 | 0.80 | ALDH1A1 (0.45) | ALDH1A1GAASLC6A4HTR1AHTR3A | |
| Hydrochloric Acid SCHEMBL10423771 | 0.79 | ALDH1A1 (0.52) | ALDH1A1GAASLC6A4HTR1AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |