Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372958 | 0.94 | KMT2A (0.67) | MEN1KMT2AADRB2ADRB3ADRB1 | |
| SCHEMBL9378576 | 0.91 | SIGMAR1 (0.56) | MEN1KMT2AADRB2ADRB1SIGMAR1 | |
| SCHEMBL4019779 | 0.86 | MEN1 (0.78) | MEN1KMT2AADRB2SIGMAR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4015079 | 0.84 | MEN1 (0.76) | MEN1KMT2AADRB2ADRB3ADRB1 | |
| SCHEMBL8100061 | 0.83 | MEN1 (0.53) | MEN1KMT2ASIGMAR1BCHE | |
| SCHEMBL8091786 | 0.81 | SIGMAR1 (0.60) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL8092627 | 0.81 | SIGMAR1 (0.60) | MEN1KMT2ASIGMAR1SMN1; SMN2GAA | |
| SCHEMBL9752913 | 0.78 | SIGMAR1 (0.56) | MEN1KMT2ASIGMAR1SMN1; SMN2 | |
| SCHEMBL8099094 | 0.78 | SIGMAR1 (0.57) | MEN1KMT2ASIGMAR1SMN1; SMN2BCHE | |
| SCHEMBL8096269 | 0.78 | SIGMAR1 (0.56) | MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |