SCHEMBL8101971

SCHEMBL8101971

Cc1nc(-c2cccc3c(N)cccc23)no1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.50
PDK2 Q15119 1/20 0.44
HSD17B10 Q99714 5/20 0.43
ALDH1A1 P00352 4/20 0.43
HPGD P15428 4/20 0.43
TSHR P16473 4/20 0.43
TDP1 Q9NUW8 3/20 0.43
CYP3A4 P08684 2/20 0.43
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
ACE2 Q9BYF1 1/20 0.42
ELANE P08246 2/20 0.41
KDM4E B2RXH2 4/20 0.40
MAPT P10636 3/20 0.40
GAA P10253 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
S1PR1 P21453 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7433112 0.84 BCHE (0.58) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL12267179 0.83 L3MBTL1 (0.53) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL31211703 0.80 MAPT (0.47) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL20073814 0.80 MAPT (0.47) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL12267178 0.76 MAPT (0.49) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL12881070 0.75 L3MBTL1 (0.45) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL12881102 0.75 L3MBTL1 (0.45) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL12267184 0.74 L3MBTL1 (0.51) L3MBTL1PDK2HSD17B10ALDH1A1HPGD
SCHEMBL8112426 0.74 TDP1 (0.51) L3MBTL1ALDH1A1HPGDTDP1MAPT
SCHEMBL12881115 0.74 PARP1 (0.47) L3MBTL1PDK2HSD17B10ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
EP-0975593-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-02 EP disclosed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed
WO-1998050358-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed