SCHEMBL7433112

SCHEMBL7433112

Cc1nc(-c2ccccc2N)no1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.58
ACHE P22303 1/20 0.58
ACE2 Q9BYF1 1/20 0.57
L3MBTL1 Q9Y468 2/20 0.50
SENP7 Q9BQF6 2/20 0.49
PDK2 Q15119 1/20 0.47
MAPT P10636 3/20 0.47
HSD17B10 Q99714 3/20 0.47
GAA P10253 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.43
ADRA1A P35348 1/20 0.43
ADRA1B P35368 1/20 0.43
NPC1 O15118 5/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
RAB9A P51151 4/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8101971 0.84 L3MBTL1 (0.50) BCHEACHEACE2L3MBTL1SENP7
SCHEMBL12660084 0.81 NPC1 (0.62) L3MBTL1SENP7PDK2MAPTHSD17B10
SCHEMBL31211703 0.80 MAPT (0.47) BCHEACHEACE2L3MBTL1PDK2
SCHEMBL20073814 0.80 MAPT (0.47) BCHEACHEACE2L3MBTL1PDK2
SCHEMBL9987876 0.78 L3MBTL1 (0.50) L3MBTL1SENP7PDK2MAPTHSD17B10
SCHEMBL4386662 0.78 CASP3 (0.68) L3MBTL1SENP7PDK2MAPTHSD17B10
SCHEMBL14914829 0.78 SMN1; SMN2 (0.55) L3MBTL1SENP7PDK2MAPTHSD17B10
SCHEMBL29640815 0.77 S1PR1 (0.46) ACE2L3MBTL1PDK2MAPTHSD17B10
SCHEMBL11487507 0.76 BCHE (0.81) BCHEACHEACE2L3MBTL1SENP7
Hydrochloric Acid SCHEMBL18172049 0.76 ADRA1A (0.51) BCHEACHEL3MBTL1SENP7PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0972773-A1 2-Oxadiazolyl- or 2-thiadiazolyl-phenylcarbamate and -phenylurea derivatives, their preparation and their use as intermediates GLAXO GROUP LIMITED (GB) 2000-01-19 EP disclosed
EP-0640081-B1 SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT4 ANTAGONISTS GLAXO GROUP LTD (GB) 2000-01-12 EP disclosed
US-5618827-A TREATING GASTROINTESTINAL, URINARY, CARDIOVASCULAR, CENTRAL NERVOUS SYTEM DISORDERS GLAXO GROUP LIMITED (GB) 1997-04-08 US disclosed
EP-0640081-A1 SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS GLAXO GROUP LIMITED (GB) 1995-03-01 EP disclosed
WO-1993020071-A1 SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS GLAXO GROUP LIMITED (GB) 1993-10-14 WO disclosed
US-4810282-A 3-ORTHO-(ISOXAZOLYL,ISOTHIAZOLYL, PYRAZOLYL,THIADIAZOLYL, OXADIAZOLYL AND TRIAZOLYL BENZENESULFONUREYLENE-1,2,4-TRIAZOLES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-03-07 US disclosed
EP-0083975-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-11-19 EP disclosed
US-4695311-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-09-22 US disclosed
US-4606755-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-08-19 US disclosed
US-4514214-A Herbicidal sulfamates E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-30 US disclosed
US-4511392-A N--/PYRIMIDIN-2-YLAMINOCARBENYL/-HETERO-SUBSTITUETED BENZENSESULFO E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-16 US disclosed
US-4475944-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-10-09 US disclosed