Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.60 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320354 | 1.00 | SLC9A1 (0.60) | SLC9A1GPR88HTR2AHTR2CHTR2B | |
| SCHEMBL9382461 | 0.85 | SLC9A1 (0.45) | SLC9A1GPR88EPHX2APPMCL1 | |
| SCHEMBL1223675 | 0.84 | SLC9A1 (0.53) | SLC9A1GPR88HTR2AHTR2CHTR2B | |
| SCHEMBL1223671 | 0.84 | SLC9A1 (0.53) | SLC9A1GPR88HTR2AHTR2CHTR2B | |
| SCHEMBL5675828 | 0.84 | GPR88 (0.46) | SLC9A1GPR88HTR2AHTR2CHTR2B | |
| SCHEMBL6250729 | 0.83 | MAPT (0.51) | GPR88EPHX2L3MBTL1MCL1ALDH1A1 | |
| SCHEMBL17590033 | 0.83 | MCL1 (0.55) | SLC9A1GPR88EPHX2APPTRPM5 | |
| SCHEMBL15208924 | 0.83 | MCL1 (0.55) | SLC9A1GPR88EPHX2APPTRPM5 | |
| SCHEMBL17146213 | 0.83 | MCL1 (0.55) | SLC9A1GPR88EPHX2APPTRPM5 | |
| SCHEMBL13929891 | 0.83 | MCL1 (0.55) | SLC9A1GPR88EPHX2APPTRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |