Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | GPR4 | P46093 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117309 | 0.89 | GPR119 (0.51) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL8111848 | 0.89 | GPR119 (0.52) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL22834092 | 0.86 | OPRD1 (0.51) | GPR119GPR4TACR1OPRD1OPRK1 | |
| SCHEMBL22265462 | 0.82 | GPR119 (0.52) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL14782776 | 0.80 | GPR119 (0.48) | GPR119GPR4TACR1 | |
| SCHEMBL22265595 | 0.80 | GPR119 (0.51) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL22309112 | 0.80 | MEN1 (0.51) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL31338779 | 0.80 | GPR119 (0.51) | GPR119TACR1CCNT1OPRD1OPRK1 | |
| SCHEMBL20015326 | 0.80 | GPR119 (0.60) | GPR119CCNT1KMT2A | |
| SCHEMBL22265768 | 0.79 | TACR1 (0.43) | GPR119GPR4TACR1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048878-A | Substituted piperidine derivatives as selective agonists of 5-HT receptors | MERCK SHARP & DOHME LTD. (GB) | 2000-04-11 | — | — | US | disclosed |