Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30514077 | 0.87 | BCAT2 (0.74) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL210767 | 0.87 | BCAT2 (0.74) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL1113049 | 0.85 | BCAT2 (0.47) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL31012518 | 0.84 | BCAT2 (0.71) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| Hydrochloric Acid SCHEMBL16463881 | 0.84 | BCAT2 (0.71) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL1110181 | 0.84 | BCAT2 (0.71) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL8813905 | 0.82 | ALDH1A1 (0.56) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL967996 | 0.82 | ALDH1A1 (0.56) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E | |
| SCHEMBL28808102 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL17475571 | 0.80 | ALDH1A1 (0.54) | BCAT2CSNK1A1TYRO3DYRK1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208960-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | TAKEDA PHARMACEUTICALS U.S.A., INC. | 2024-06-27 | — | — | US | disclosed |
| US-11753404-B2 | Aminothiazole compounds as c-Kit inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4121082-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | Fog Pharmaceuticals, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| US-20220033392-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | TAKEDA PHARMACEUTICALS U.S.A., INC. | 2022-02-03 | — | — | US | disclosed |
| WO-2021188659-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | FOG PHARMACEUTICALS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| US-11001580-B2 | Aminothiazole compounds as c-Kit inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2021-05-11 | — | — | US | disclosed |
| US-20190352298-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | TAKEDA PHARMACEUTICALS U.S.A., INC. | 2019-11-21 | — | — | US | disclosed |
| EP-3555090-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018112136-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| CN-103980212-A | Method for synthesizing benzodiazepine heterocyclic derivative by one-pot method | NANJING UNIVERSITY OF TECHNOLOGY | 2014-08-13 | — | — | CN | disclosed |
| US-6160194-A | Soil decontamination using ferric chelates and peroxide | THE CONNECTICUT AGRICULTURAL EXPERIMENT STATION (US) | 2000-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033392-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | KIT, TNNI3K, CKS1B | BCAT2 305/4885CSNK1A1 27/4885TYRO3 284/4885 |
| US-11753404-B2 | Aminothiazole compounds as c-Kit inhibitors | KIT, TNNI3K, CKS1B | BCAT2 305/4885CSNK1A1 27/4885TYRO3 284/4885 |
| US-11001580-B2 | Aminothiazole compounds as c-Kit inhibitors | KIT, TNNI3K, CKS1B | BCAT2 270/4885CSNK1A1 23/4885TYRO3 271/4885 |
| US-20190352298-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | KIT, TNNI3K, CKS1B | BCAT2 270/4885CSNK1A1 23/4885TYRO3 271/4885 |
| US-20240208960-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | KIT, TNNI3K, CKS1B | BCAT2 305/4885CSNK1A1 27/4885TYRO3 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.