Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 7/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | DRD5 | P21918 | 3/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179759 | 0.89 | KDM4E (0.69) | KDM4EGAASIGMAR1DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL11622828 | 0.87 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL18754269 | 0.86 | KDM4E (0.75) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL13079491 | 0.85 | KDM4E (0.78) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL2093634 | 0.83 | KDM4E (0.61) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL7739933 | 0.83 | MAPT (0.61) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL4400393 | 0.83 | KDM4E (0.61) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL6184036 | 0.83 | MAPT (0.58) | GAASIGMAR1DRD4HTR1ADRD2 | |
| SCHEMBL10366646 | 0.83 | KDM4E (0.61) | KDM4EGAASIGMAR1DRD4HTR1A | |
| SCHEMBL5836202 | 0.82 | KCNH2 (0.69) | KDM4ESIGMAR1DRD4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810206-B1 | Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| US-6087304-A | ANTIARRHYTHMIC PHARMACEUTICALS HAVING A CARDIOPROTECTIVE COMPONENT FOR INFARCT PROPHYLAXIS AND INFARCT TREATMENT AND FOR THE TREATMENT OF ANGINA PECTORIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-07-11 | — | — | US | disclosed |
| EP-0810206-A1 | Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-03 | — | — | EP | disclosed |