Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.71 |
| ▸ | DRD2 | P14416 | 10/20 | 0.67 |
| ▸ | DRD3 | P35462 | 8/20 | 0.67 |
| ▸ | HTR1A | P08908 | 7/20 | 0.67 |
| ▸ | HTR2A | P28223 | 7/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.67 |
| ▸ | DRD1 | P21728 | 3/20 | 0.65 |
| ▸ | DRD5 | P21918 | 3/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 5/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11637430 | 0.93 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL11637592 | 0.93 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL5179759 | 0.91 | KDM4E (0.69) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL11618967 | 0.89 | CYP2D6 (0.70) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL16666733 | 0.89 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11622828 | 0.89 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL9393977 | 0.89 | KDM4E (0.67) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL14459608 | 0.89 | KDM4E (0.88) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL16676579 | 0.88 | KDM4E (0.97) | KDM4EGAASIGMAR1DRD2DRD3 | |
| SCHEMBL16666842 | 0.88 | KDM4E (0.69) | KDM4EGAASIGMAR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170115276-A1 | SPECIFIC MODULATORS OF CONNEXIN HEMICHANNELS | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE º (CL) | 2017-04-27 | — | — | US | disclosed |
| US-20170115276-A1 | SPECIFIC MODULATORS OF CONNEXIN HEMICHANNELS | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE º (CL) | 2017-04-27 | — | — | US | disclosed |
| EP-3156039-A1 | SPECIFIC MODULATORS OF CONNEXIN HEMICHANNELS | Pontificia Universidad Católica de Chile (CL) | 2017-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170115276-A1 | SPECIFIC MODULATORS OF CONNEXIN HEMICHANNELS | GJA1, GJB2, TNNC1 | KDM4E 4297/4885GAA 4775/4885SIGMAR1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.