Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091161 | 0.98 | TSHR (0.53) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL10999834 | 0.88 | MEN1 (0.51) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL10436410 | 0.85 | CPA1 (0.57) | TSHRLMNAMEN1KMT2ACYP2C19 | |
| SCHEMBL10926758 | 0.85 | MEN1 (0.49) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL9705623 | 0.84 | LMNA (0.54) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL8102671 | 0.84 | LMNA (0.50) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL8953727 | 0.84 | LMNA (0.50) | TSHRLMNAMEN1KMT2ACYP2C19 | |
| SCHEMBL1862886 | 0.84 | LMNA (0.54) | GSK3BTSHRLMNAMEN1KMT2A | |
| SCHEMBL1857686 | 0.84 | LMNA (0.50) | TSHRLMNAMEN1KMT2ACYP2C19 | |
| SCHEMBL4365310 | 0.84 | LMNA (0.50) | TSHRLMNAMEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054917-B1 | 6- AND 4-SUBSTITUTED-1-AZABICYCLO(3.2.0)HEPTAN-3,7-DIONE-2-CARBOXYLATES | MERCK & CO. INC. (US) | 1988-03-09 | — | — | EP | claimed |
| EP-1031572-A1 | PYRIDYLPYRROLE DERIVATIVES | Sankyo Company Limited (JP) | 2000-08-30 | — | — | EP | disclosed |
| US-5756765-A | BACTERICIDES AND ANTIBIOTICS | CHONG KUN DANG CORP. (KR) | 1998-05-26 | — | — | US | disclosed |
| US-5750735-A | CHEMICAL INTERMEDIATES FOR ANTIBIOTICS | AMERICAN CYANAMID COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5744465-A | Method of inhibiting a β-lactamase enzyme by administering novel 2-thiosubstituted carbapenems | AMERICAN CYANAMID COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| US-5641770-A | THIENAMYCINS ANTIBIOTICS | CHONG KUN DANG CORP. (KR) | 1997-06-24 | — | — | US | disclosed |
| US-5623081-A | USING BENZYLOXYACETALDEHYDE DIMETHYL ETHER, HALOGENATED 1-PHENYLMETHOXY-4-PENTEN-2-OL; CYCLIZATION | LIN YANG-I (US) | 1997-04-22 | — | — | US | disclosed |
| US-5602118-A | A 2-((2-SUBSTITUTED ALKYL)FUR-3-YL)-THIO-),3-CARBOXY-2-CARBOPENEM DERIVATIVES; EFFECTIVE AGAINST BETA-LACTAM ANTIBIOTIC-RESISTANT BACTERIA | AMERICAN CYANAMID COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0674640-A1 | 2-(2-SUBSTITUTED PYRROLIDIN-4-YL)THIO-CARBAPENEM DERIVATIVES | CHONG KUN DANG CORP (KR) | 1995-10-04 | — | — | EP | disclosed |
| US-5380860-A | Preparation of beta-ketoesters useful in preparing quinolone antibiotics | PFIZER INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0237027-A2 | 6-(Disubstituted amino) carbapenam compounds | Sanraku Incorporated (JP) | 1987-09-16 | — | — | EP | disclosed |
| EP-0060416-B1 | NEW BETA-LACTAM ACETIC ACID DERIVATIVES, THE PROCESS FOR PREPARING THEM, AND THEIR USE AS INTERMEDIATES FOR 1-AZABICYCLO(3.2.0.)HEPT-2-ENE ANTIBIOTICS | GRUPPO LEPETIT S.P.A. (IT) | 1986-08-20 | — | — | EP | disclosed |
| US-4576746-A | Novel β-lactam acetic acid derivatives | GRUPPO LEPETIT, S.P.A. (IT) | 1986-03-18 | — | — | US | disclosed |
| EP-0160876-A1 | 1-Hetero-6-/1-Hydroxyethyl/-2-SR8-1-carbadethiapen-2-EM-3-carboxylic acids | MERCK & CO. INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| EP-0113101-A1 | 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters | MERCK & CO. INC. (US) | 1984-07-11 | — | — | EP | disclosed |
| EP-0093915-A1 | Novel beta-lactam derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1983-11-16 | — | — | EP | disclosed |
| EP-0071908-A1 | 1-, and 1,1-disubstituted-6-substituted-2-carbamimidoyl-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition containing the same | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0060416-A1 | New beta-lactam acetic acid derivatives, the process for preparing them, and their use as intermediates for 1-azabicyclo(3.2.0.)hept-2-ene antibiotics | GRUPPO LEPETIT S.P.A. (IT) | 1982-09-22 | — | — | EP | disclosed |
| US-4350631-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0054917-A2 | 6- and 4-Substituted-1-azabicyclo(3.2.0)heptan-3,7-dione-2-carboxylates | MERCK & CO. INC. (US) | 1982-06-30 | — | — | EP | disclosed |