Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | RARB | P10826 | 4/20 | 0.45 |
| ▸ | RARG | P13631 | 4/20 | 0.45 |
| ▸ | RARA | P10276 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106415 | 0.87 | KMT2A (0.48) | KMT2ARAB9AGAACYP26A1CYP26B1 | |
| SCHEMBL8093059 | 0.86 | CYP26A1 (0.44) | KMT2ACYP26A1CYP26B1CYP3A4RARB | |
| SCHEMBL8093046 | 0.83 | RARB (0.64) | KMT2ACYP26A1CYP26B1CYP3A4RARB | |
| SCHEMBL8100687 | 0.83 | CYP3A4 (0.47) | KMT2ARAB9AGAACYP3A4ALDH1A1 | |
| SCHEMBL8102916 | 0.81 | RARB (0.51) | KMT2ACYP26A1CYP26B1CYP3A4RARB | |
| SCHEMBL8839182 | 0.80 | KMT2A (0.54) | KMT2ARAB9AGAACYP26A1CYP26B1 | |
| SCHEMBL8556266 | 0.80 | RARG (0.45) | KMT2ARAB9ACYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8103042 | 0.79 | RARB (0.47) | KMT2ACYP26A1CYP26B1CYP3A4RARB | |
| SCHEMBL8839024 | 0.79 | KMT2A (0.56) | KMT2ARAB9AGAACYP26A1CYP26B1 | |
| SCHEMBL8556008 | 0.78 | RXRA (0.48) | KMT2ACYP26A1CYP26B1CYP3A4RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |