SCHEMBL8106415

SCHEMBL8106415

CC(=O)NC(C(=O)Nc1ccc(C(=O)OCc2ccccc2)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.48
RAB9A P51151 2/20 0.48
GAA P10253 1/20 0.48
CYP3A4 P08684 7/20 0.48
ALDH1A1 P00352 2/20 0.48
TSHR P16473 2/20 0.48
TP53 P04637 1/20 0.46
MAPT P10636 3/20 0.45
CYP26A1 O43174 5/20 0.45
CYP26B1 Q9NR63 3/20 0.45
MEN1 O00255 6/20 0.43
MAPK1 P28482 2/20 0.43
RARA P10276 2/20 0.43
RARB P10826 2/20 0.43
RARG P13631 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KDM4E B2RXH2 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8100687 0.89 CYP3A4 (0.47) KMT2ARAB9AGAACYP3A4ALDH1A1
SCHEMBL8102765 0.87 KMT2A (0.50) KMT2ARAB9AGAACYP3A4ALDH1A1
SCHEMBL8100633 0.84 RARB (0.61) KMT2ARAB9ACYP3A4ALDH1A1TSHR
SCHEMBL8839182 0.79 KMT2A (0.54) KMT2ARAB9AGAACYP3A4ALDH1A1
SCHEMBL8555833 0.78 RXRA (0.46) KMT2ACYP3A4ALDH1A1TSHRMAPT
SCHEMBL8839024 0.77 KMT2A (0.56) KMT2ARAB9AGAACYP3A4ALDH1A1
SCHEMBL8103130 0.77 BACE1 (0.42) CYP3A4ALDH1A1TSHRCYP26A1CYP26B1
SCHEMBL8555829 0.76 RARB (0.48) KMT2ACYP3A4ALDH1A1TSHRCYP26A1
SCHEMBL6148024 0.75 CYP3A4 (0.47) KMT2ARAB9ACYP3A4ALDH1A1MAPT
SCHEMBL8093059 0.75 CYP26A1 (0.44) KMT2ACYP3A4ALDH1A1TSHRCYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051243-A USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-04-18 US disclosed
US-5709867-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-01-20 US disclosed