Sugi Predict

Sugi Predict / Compounds / Alfuzosin

Alfuzosin

Alfuzosin

SCHEMBL8102871

[2H]C([2H])([2H])Oc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC([2H])([2H])[2H]

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Alfuzosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADRA1D known ✓ P25100 4/20 0.89
▸ ADRA1A known ✓ P35348 4/20 0.89
▸ ADRA1B known ✓ P35368 4/20 0.89
▸ KDM4E B2RXH2 6/20 0.89
▸ ALDH1A1 P00352 6/20 0.89
▸ HPGD P15428 6/20 0.89
▸ GLA P06280 5/20 0.89
▸ HSD17B10 Q99714 5/20 0.89
▸ GAA P10253 4/20 0.89
▸ KCNH2 Q12809 3/20 0.89
▸ SLC22A1 O15245 2/20 0.89
▸ ADRA2A P08913 2/20 0.89
▸ ADRA2B P18089 2/20 0.89
▸ ADRA2C P18825 2/20 0.89
▸ ACHE P22303 2/20 0.89
▸ LMNA P02545 2/20 0.89
▸ SLC6A2 P23975 1/20 0.89
▸ DRD3 P35462 1/20 0.89
▸ MAPK1 P28482 2/20 0.45
▸ TP53 P04637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alfuzosin SCHEMBL8102142 0.97 KDM4E (0.83) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL29497289 0.94 KDM4E (1.00) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL34477 0.94 KDM4E (1.00) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL2950056 0.94 KDM4E (1.00) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL29355511 0.94 KDM4E (1.00) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL415972 0.94 KDM4E (1.00) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL4744369 0.93 KDM4E (0.98) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL179910 0.93 KDM4E (0.98) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL2851348 0.93 KDM4E (0.98) KDM4EALDH1A1HPGDGLAHSD17B10
Alfuzosin SCHEMBL29492949 0.93 KDM4E (0.98) KDM4EALDH1A1HPGDGLAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080039473-A1 PREPARATION AND UTILITY OF SUBSTITUTED QUINAZOLINE COMPOUNDS WITH ALPHA-ADRENERGIC BLOCKING EFFECTS AUSPEX PHARMACEUTICALS, INC. (US) 2008-02-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080039473-A1 PREPARATION AND UTILITY OF SUBSTITUTED QUINAZOLINE COMPOUNDS WITH ALPHA-ADRENERGIC BLOCKING EFFECTS ADRB1, ADRB2, ADRB3 ADRA1D 9/4885ADRA1A 8/4885ADRA1B 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.