Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411164 | 0.90 | NPC1 (0.45) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL27519085 | 0.75 | PLG (0.41) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7413034 | 0.75 | RAB9A (0.43) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL12994633 | 0.72 | NPC1 (0.60) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL13102959 | 0.71 | RAB9A (0.59) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL1275920 | 0.70 | ALDH1A1 (0.70) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL17169067 | 0.69 | IDO1 (0.42) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL5851828 | 0.68 | CA12 (0.62) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL28904427 | 0.67 | RAB9A (0.54) | NPC1POLBMAPTRAB9AALDH1A1 | |
| SCHEMBL21597432 | 0.67 | TDP1 (0.59) | NPC1POLBMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |