Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 1.00 |
| ▸ | CTSB | P07858 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248612 | 1.00 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2244605 | 0.90 | CTSB (1.00) | CTSKCTSB | |
| SCHEMBL2243106 | 0.90 | CTSK (0.82) | CTSKCTSB | |
| SCHEMBL2243955 | 0.89 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2241261 | 0.88 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2248298 | 0.88 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2241195 | 0.88 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL14563104 | 0.88 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL2243628 | 0.87 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2244031 | 0.86 | CTSK (0.75) | CTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001129-A9 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | WO | disclosed |
| WO-2009001129-A1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |