Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | OTUD7B | Q6GQQ9 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476995 | 0.92 | SMN1; SMN2 (0.55) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL7102226 | 0.92 | — | — | |
| SCHEMBL15326919 | 0.85 | GSK3B (0.47) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL5178865 | 0.80 | CYP1A2 (0.80) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL9793307 | 0.78 | CYP1A2 (0.67) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL4606296 | 0.77 | ALOX15 (0.42) | GSK3BSMN1; SMN2CYP1A2GAAALOX15 | |
| SCHEMBL2420515 | 0.74 | CYP1A2 (0.77) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL2511237 | 0.74 | CYP1A2 (0.53) | GSK3BSMN1; SMN2CYP1A2AKT1ALDH1A1 | |
| SCHEMBL626994 | 0.72 | GSK3B (0.49) | GSK3BSMN1; SMN2CYP1A2MAPTGAA | |
| SCHEMBL3835689 | 0.72 | CYP1A2 (0.47) | GSK3BSMN1; SMN2CYP1A2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| JP-2000007674-A | NOVEL 5,10-DIHYDRODIPYRIDO-[2,3-B:2,3-E]PYRAZINE COMPOUND, 5,10-DIHYDRODIPYRIDO-[2,3-B:3,2-E]PYRAZINE COMPOUND, THEIR PRODUCTION, AND ANTITUMOR AGENT CONTAINING THEM | ADIR | 2000-01-11 | — | — | JP | disclosed |