Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 12/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337375 | 0.87 | HTR5A (0.47) | ALOX15HSD17B10GSK3BCYP1A2SMN1; SMN2 | |
| SCHEMBL4162589 | 0.87 | CYP1A2 (0.50) | ALOX15HSD17B10CYP1A2SMN1; SMN2GAA | |
| SCHEMBL2400223 | 0.79 | — | — | |
| SCHEMBL626994 | 0.77 | GSK3B (0.49) | ALOX15HSD17B10GSK3BCYP1A2SMN1; SMN2 | |
| SCHEMBL29361773 | 0.77 | MB (0.53) | GSK3BCYP1A2SMN1; SMN2IDH1ADRA2A | |
| SCHEMBL13801620 | 0.77 | ADRA2A (0.38) | HSD17B10GSK3BCYP1A2SMN1; SMN2IDH1 | |
| SCHEMBL626229 | 0.77 | MB (0.53) | GSK3BCYP1A2SMN1; SMN2IDH1ADRA2A | |
| SCHEMBL8103221 | 0.77 | GSK3B (0.50) | ALOX15HSD17B10GSK3BCYP1A2SMN1; SMN2 | |
| SCHEMBL17802889 | 0.76 | IDH1 (0.46) | GSK3BCYP1A2SMN1; SMN2GAAIDH1 | |
| SCHEMBL17803303 | 0.75 | IDH1 (0.45) | CYP1A2SMN1; SMN2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469858-B1 | NON-NUCLEOSIDIC INHIBITORS OF REVERSE TRANSCRIPTASE AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCERS OF CELL DIFFERENTIATION | IST SUPERIORE SANITA (IT) | 2008-07-09 | — | — | EP | claimed |
| US-20060166970-A1 | Non-nucleosidic inhibitors of reverse transcriptase as antagonists of cell proliferation and inducers of cell differentiation | ISTITUTO SUPERIORE DI SANITA' (IT) | 2006-07-27 | — | — | US | claimed |
| EP-1469858-A1 | NON-NUCLEOSIDIC INHIBITORS OF REVERSE TRANSCRIPTASE AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCERS OF CELL DIFFERENTIATION | Istituto Superiore di Sanità (IT) | 2004-10-27 | — | — | EP | claimed |
| WO-2003055493-A1 | NON-NUCLEOSIDIC INHIBITORS OF REVERSE TRANSCRIPTASE AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCERS OF CELL DIFFERENTIATION | ISTITUTO SUPERIORE DI SANITA` (IT) | 2003-07-10 | — | — | WO | claimed |
| JP-5163272-A | — | — | None | — | — | JP | disclosed |
| JP-4257584-A | — | — | None | — | — | JP | disclosed |
| JP-4178386-A | — | — | None | — | — | JP | disclosed |
| CN-103804378-A | Preparation method for 5,11-dihydro-6H-bispyridino-[3,2-b:2',3'-e][1,4]diazepines | SHANGHAI DESANO CHEMICAL PHARM | 2014-05-21 | — | — | CN | disclosed |
| CN-103804378-A | Preparation method for 5,11-dihydro-6H-bispyridino-[3,2-b:2',3'-e][1,4]diazepines | SHANGHAI DESANO CHEMICAL PHARM | 2014-05-21 | — | — | CN | disclosed |
| EP-1469858-B1 | NON-NUCLEOSIDIC INHIBITORS OF REVERSE TRANSCRIPTASE AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCERS OF CELL DIFFERENTIATION | IST SUPERIORE SANITA (IT) | 2008-07-09 | — | — | EP | disclosed |
| US-20060166970-A1 | Non-nucleosidic inhibitors of reverse transcriptase as antagonists of cell proliferation and inducers of cell differentiation | ISTITUTO SUPERIORE DI SANITA' (IT) | 2006-07-27 | — | — | US | disclosed |
| EP-1469858-A1 | NON-NUCLEOSIDIC INHIBITORS OF REVERSE TRANSCRIPTASE AS ANTAGONISTS OF CELL PROLIFERATION AND INDUCERS OF CELL DIFFERENTIATION | Istituto Superiore di Sanità (IT) | 2004-10-27 | — | — | EP | disclosed |
| JP-H04257584-A | 5,11-DIHYDRO-6H-DIPYRID(3,2-B:2',3'-E)(1,4)DIAZEPINE AND COMPOSITION FOR PREVENTION OR TREATMENT OF HIV INFECTION CONTAINING THIS COMPOUND | BOEHRINGER INGELHEIM PHARMACEUT INC | 1992-09-11 | — | — | JP | disclosed |
| JP-H04178386-A | 5,11-DIHYDRO-6H-DIPYRIDO(3,2-B:2',3'-E)(1,4)DIAZEPINE AND ITS FORMULATION FOR USE IN PREVENTION OR TREATMENT OF HIV INFECTION | BOEHRINGER INGELHEIM PHARMACEUT INC | 1992-06-25 | — | — | JP | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0429987-A3 | 5,11-DIHYDRO-6H-DIPYRIDO(3,2-B:2',3'-E) (1,4)DIAZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0429987-A2 | 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-06-05 | — | — | EP | disclosed |
| EP-0429987-A2 | 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-06-05 | — | — | EP | disclosed |