Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21630707 | 0.84 | CFTR (0.56) | F12LMNAMAPTBAZ2BPARP1 | |
| SCHEMBL21114784 | 0.83 | CTSK (0.48) | F12LMNAMAPTBAZ2BPARP1 | |
| SCHEMBL29357232 | 0.83 | CTSK (0.48) | F12LMNAMAPTBAZ2BPARP1 | |
| SCHEMBL8713133 | 0.82 | TRPV1 (0.44) | F12PARP1TNKS2PARP2TRPV1 | |
| SCHEMBL6475020 | 0.79 | F12 (0.43) | F12LMNAMAPTBAZ2BPARP1 | |
| SCHEMBL2241936 | 0.78 | MAPT (0.69) | LMNAMAPTBAZ2BPABPC1ATM | |
| SCHEMBL29357331 | 0.78 | MAPT (0.69) | LMNAMAPTBAZ2BPABPC1ATM | |
| Acetic Acid SCHEMBL8714196 | 0.78 | MAPT (0.68) | LMNAMAPTBAZ2BPABPC1ATM | |
| SCHEMBL6475935 | 0.75 | PARP1 (0.43) | F12LMNAMAPTBAZ2BPARP1 | |
| SCHEMBL21588265 | 0.74 | PARP1 (0.49) | F12PARP1TNKS2PARP2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716661-B1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS INC (US) | 2000-04-05 | — | — | EP | disclosed |
| EP-0716661-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | disclosed |