Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.69 |
| ▸ | HTR2C | P28335 | 10/20 | 0.69 |
| ▸ | HTR1D | P28221 | 5/20 | 0.56 |
| ▸ | HTR1B | P28222 | 5/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | HTR5A | P47898 | 2/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | HTR1F | P30939 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113712 | 0.83 | HTR1A (0.60) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL8104562 | 0.81 | HTR1A (0.69) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL8112400 | 0.80 | HTR1A (0.59) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL8113317 | 0.76 | HTR1A (0.60) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL2998441 | 0.76 | HTR1A (0.71) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL9274415 | 0.76 | HTR1A (0.57) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL6941530 | 0.75 | HTR1A (0.75) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL8103630 | 0.74 | HTR1A (0.62) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL31574201 | 0.73 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL22612481 | 0.73 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637307-B1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2000-11-08 | — | — | EP | claimed |
| US-5607957-A | CONTAINING ALSO INDOLE, BENZOFURAN, BENZTHIOPHENE OR INDAZOLE MOIETY; METHOD FOR TREATMENT AND/OR PREVENTION OF CLINICAL CONDITIONS FOR WHICH A SELECTIVE AGONIST OF 5-HT1-LIKE RECEPTORS IS INDICATED | MERCK SHARP & DOHME LTD. (GB) | 1997-03-04 | — | — | US | claimed |
| EP-0637307-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-02-08 | — | — | EP | claimed |
| WO-1993020066-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1993-10-14 | — | — | WO | claimed |
| EP-0637307-B1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2000-11-08 | — | — | EP | disclosed |
| US-5607957-A | CONTAINING ALSO INDOLE, BENZOFURAN, BENZTHIOPHENE OR INDAZOLE MOIETY; METHOD FOR TREATMENT AND/OR PREVENTION OF CLINICAL CONDITIONS FOR WHICH A SELECTIVE AGONIST OF 5-HT1-LIKE RECEPTORS IS INDICATED | MERCK SHARP & DOHME LTD. (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0637307-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993020066-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |