Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CCR6 | P51684 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537728 | 0.88 | CYP1A2 (0.42) | CYP1A2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL6537685 | 0.80 | KMT2A (0.41) | NPC1KMT2AMEN1RAB9AKDM4E | |
| SCHEMBL25647610 | 0.79 | CCR8 (0.42) | KMT2ARAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL17708236 | 0.72 | CYP1A2 (0.61) | CYP1A2TSHRSMN1; SMN2TDP1CCR6 | |
| SCHEMBL25647609 | 0.72 | NQO2 (0.41) | KMT2AMEN1KDM4ERECQLMAPT | |
| SCHEMBL6537634 | 0.71 | GRIN2D (0.49) | CYP1A2NPC1KMT2AKDM4ETSHR | |
| SCHEMBL25647617 | 0.70 | CFB (0.36) | KMT2ACCR8 | |
| SCHEMBL8119259 | 0.69 | KDM4E (0.52) | CYP1A2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL6537811 | 0.69 | TDP1 (0.44) | NPC1KMT2AMEN1RAB9AKDM4E | |
| SCHEMBL20877299 | 0.69 | BCHE (0.43) | NPC1KMT2AMEN1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736020-B1 | 6-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2000-04-26 | — | — | EP | disclosed |
| CN-1046718-C | 6- (2-imidazolidinylideneamino) quinoline compounds as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 1999-11-24 | — | — | CN | disclosed |
| US-5804587-A | 6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1998-09-08 | — | — | US | disclosed |
| US-5739148-A | RESPIRATORY SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, VISION DISORDERS | THE PROCTER & GAMBLE COMPANY | 1998-04-14 | — | — | US | disclosed |
| CN-1137793-A | 6- (2-imidazolinylamino) quinoline compounds as alpha 2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 1996-12-11 | — | — | CN | disclosed |
| US-5578607-A | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0736020-A1 | 6-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995016683-A1 | 6-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-06-22 | — | — | WO | disclosed |