Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537685 | 0.82 | KMT2A (0.41) | TDP1CCR8CASP6TSHRMAPK1 | |
| SCHEMBL27174894 | 0.78 | TDP1 (0.48) | TDP1FBP1CASP6TSHRMAPK1 | |
| SCHEMBL30799237 | 0.78 | TDP1 (0.48) | TDP1FBP1CASP6TSHRMAPK1 | |
| SCHEMBL11003986 | 0.78 | TDP1 (0.48) | TDP1FBP1CASP6TSHRMAPK1 | |
| SCHEMBL6537669 | 0.77 | LMNA (0.51) | TDP1FBP1CASP6KMT2AALDH1A1 | |
| SCHEMBL3920360 | 0.75 | TDP1 (0.48) | TDP1TSHRMAPK1ALDH1A1VCAM1 | |
| SCHEMBL6368215 | 0.74 | CASP6 (0.50) | TDP1CCR8CASP6TSHRMAPK1 | |
| SCHEMBL20877299 | 0.74 | BCHE (0.43) | CCR8CASP6TSHRKMT2AALDH1A1 | |
| SCHEMBL6538265 | 0.74 | TDP1 (0.41) | TDP1FBP1CASP6TSHRMAPK1 | |
| SCHEMBL6537493 | 0.73 | ALDH1A1 (0.58) | TDP1FBP1CCR8CASP6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |