Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | THPO | P40225 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.50 |
| ▸ | HTR1B | P28222 | 3/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18622640 | 0.86 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8109749 | 0.84 | OPRM1 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8096608 | 0.84 | HTR1D (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8109656 | 0.84 | OPRM1 (0.68) | HTR1BOPRM1OPRK1OPRL1ADRA1D | |
| SCHEMBL3546728 | 0.83 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL30908918 | 0.83 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8103895 | 0.81 | SLC6A4 (0.69) | HTR1BHTR1ASLC6A4 | |
| SCHEMBL5705057 | 0.79 | CYP1A2 (0.72) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL3549500 | 0.79 | CYP1A2 (0.68) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL8103912 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |