Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.68 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.63 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.62 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CCR5 | P51681 | 3/20 | 0.55 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967730 | 0.90 | DRD2 (0.64) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL29110823 | 0.89 | SLC18A3 (0.66) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL22623921 | 0.84 | DRD2 (0.72) | DRD2SIGMAR1PRCPDRD1DRD4 | |
| SCHEMBL1099798 | 0.83 | SLC18A3 (0.67) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL19235999 | 0.82 | DRD2 (0.72) | DRD2SIGMAR1PRCPDRD1DRD4 | |
| SCHEMBL23374659 | 0.81 | SLC18A3 (0.56) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL12768109 | 0.81 | SLC18A3 (0.56) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL12447397 | 0.81 | SLC18A3 (0.56) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| SCHEMBL3399715 | 0.81 | DRD2 (1.00) | DRD2SLC18A3CARM1PRMT6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7259165 | 0.79 | SIGMAR1 (0.75) | DRD2SLC18A3CARM1PRMT6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233979-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9226922-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150266895-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-09-24 | — | — | US | disclosed |
| US-20150258074-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-09-17 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266895-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK10, MAP3K1 | DRD2 4744/4885SLC18A3 4082/4885CARM1 2627/4885 |
| US-20150258074-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAP3K20 | DRD2 4161/4885SLC18A3 3374/4885CARM1 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.