Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098094 | 0.84 | HTR2C (0.54) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL8098093 | 0.84 | HTR2C (0.54) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL8102597 | 0.84 | HTR2C (0.56) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL8102591 | 0.84 | HTR2C (0.56) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL8102766 | 0.81 | HTR2A (0.56) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8096201 | 0.80 | HTR2C (0.51) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL8096202 | 0.80 | HTR2C (0.51) | HTR2AHTR2CHTR2BCNR1MTNR1A | |
| SCHEMBL24737408 | 0.75 | HTR2A (0.62) | HTR2AHTR2CHTR2BSLC9A1 | |
| SCHEMBL30711641 | 0.74 | HTR2C (0.70) | HTR2AHTR2CHTR2BSLC9A1 | |
| SCHEMBL27033783 | 0.74 | HTR2C (0.70) | HTR2AHTR2CHTR2BSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |