Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 11/20 | 0.61 |
| ▸ | PTGER2 | P43116 | 10/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.55 |
| ▸ | PTGFR | P43088 | 3/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.54 |
| ▸ | PTGIR | P43119 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105303 | 1.00 | PTGER3 (0.61) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL27767297 | 0.88 | PTGER3 (0.49) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL28198833 | 0.86 | PTGER3 (0.51) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL28198834 | 0.86 | PTGER3 (0.51) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL8985158 | 0.86 | PTGER3 (0.62) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL27497043 | 0.85 | PTPN1 (0.46) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL28068734 | 0.84 | MAPT (0.54) | NFKB1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL28068832 | 0.84 | MAPT (0.54) | NFKB1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL15630767 | 0.84 | LMNA (0.58) | PTGER3PTGER2PTGER4CA1CA2 | |
| SCHEMBL28085791 | 0.84 | PTGER3 (0.44) | PTGER3PTGER2PTGER4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716661-B1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS INC (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5541286-A | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids | SCIOS NOVA INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0716661-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5444048-A | Antiinflammatory agents, analgesics | SCIOS NOVA, INC. (US) | 1995-08-22 | — | — | US | disclosed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | disclosed |