Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 1.00 |
| ▸ | FNTB | P49356 | 6/20 | 1.00 |
| ▸ | PGGT1B | P53609 | 5/20 | 1.00 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106703 | 0.82 | FNTA (0.70) | FNTAFNTBPGGT1BTAAR1 | |
| SCHEMBL8869829 | 0.81 | FNTA (0.69) | FNTAFNTBPGGT1B | |
| SCHEMBL8097474 | 0.80 | FNTA (1.00) | FNTAFNTBPGGT1BANPEPENPEP | |
| SCHEMBL8586902 | 0.80 | FNTA (1.00) | FNTAFNTBPGGT1BANPEPENPEP | |
| SCHEMBL8111003 | 0.79 | FNTA (1.00) | FNTAFNTBPGGT1BANPEPENPEP | |
| SCHEMBL8869774 | 0.78 | FNTA (0.63) | FNTAFNTBPGGT1B | |
| SCHEMBL8365755 | 0.76 | FNTA (0.61) | FNTAFNTBPGGT1BTAAR1 | |
| Trifluoroacetic Acid SCHEMBL8869217 | 0.76 | FNTA (0.61) | FNTAFNTBPGGT1B | |
| SCHEMBL8870485 | 0.75 | FNTA (0.60) | FNTAFNTBPGGT1BANPEP | |
| SCHEMBL14683877 | 0.73 | KMO (0.87) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011175-A | Inhibition of farnesyltransferase | UNIVERSITY OF PITTSBURGH (US) | 2000-01-04 | — | — | US | disclosed |
| US-5965539-A | PEPTIDOMIMETICS; ANTI-CANCER DRUGS | UNIVERISTY OF PITTSBURGH (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0794789-A4 | INHIBITORS OF PRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 1999-05-26 | — | — | EP | disclosed |
| US-5705686-A | 3-MERCAPTO-2-AMINO-PROPYLAMINOBIPHENYL DERIVATIVES; PEPTIDOMIMETICS; ANTICARCINOGENIC AGENTS | UNIVERSITY OF PITTSBURGH (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0794789-A1 | INHIBITORS OF PRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996021456-A1 | INHIBITORS OF PRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1996-07-18 | — | — | WO | disclosed |