Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.70 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.51 |
| ▸ | CBR1 | P16152 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652668 | 0.83 | MAPT (0.63) | TTRHPGDMAPTNR1I2LMNA | |
| SCHEMBL13236278 | 0.83 | TTR (1.00) | TTRMRGPRX4HPGDMAPTNR1I2 | |
| Hydrochloric Acid SCHEMBL11346813 | 0.81 | MAPT (0.67) | TTRHPGDMAPTNR1I2LMNA | |
| SCHEMBL13236301 | 0.81 | TTR (0.70) | TTRMRGPRX4HPGDMAPTNR1I2 | |
| SCHEMBL8104954 | 0.80 | FFAR1 (0.70) | TTRMRGPRX4HPGDMAPTNR1I2 | |
| SCHEMBL13264608 | 0.80 | TTR (0.76) | TTRMRGPRX4HPGDMAPTNR1I2 | |
| SCHEMBL11294313 | 0.78 | TTR (0.55) | TTRHPGDMAPTNR1I2LMNA | |
| SCHEMBL8480028 | 0.77 | MAPT (0.54) | TTRHPGDMAPTNR1I2LMNA | |
| SCHEMBL2968982 | 0.76 | L3MBTL1 (0.62) | TTRMRGPRX4HPGDMAPTLMNA | |
| SCHEMBL1340223 | 0.76 | SLC6A2 (0.51) | TTRHPGDMAPTNR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |