Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MGMT | P16455 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838615 | 0.86 | KMT2A (0.36) | KMT2AMEN1ALDH1A1TDP1CYP19A1 | |
| SCHEMBL8178850 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL8118510 | 0.76 | KMT2A (0.45) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL8115993 | 0.75 | KMT2A (0.38) | KMT2AMEN1ALDH1A1TDP1SLC6A2 | |
| SCHEMBL1089020 | 0.73 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1TDP1TSHR | |
| SCHEMBL3843256 | 0.72 | TDP1 (0.53) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL17445282 | 0.71 | TDP1 (0.40) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL8838610 | 0.71 | ALDH1A1 (0.33) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL3025068 | 0.71 | PDE7A (0.46) | KMT2AMEN1ALDH1A1TDP1LMNA | |
| SCHEMBL10694908 | 0.70 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632036-B1 | Amide derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO CO (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5614550-A | ANTICHOLESTEROL AGENTS OR ARTERIOSCLEROSIS AGENTS FOR HUMANS | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5534529-A | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632036-A2 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1995-01-04 | — | — | EP | disclosed |