Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 7/20 | 0.32 |
| ▸ | THRA | P10827 | 6/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9181295 | 0.85 | HSD17B10 (0.38) | THRBTHRAHSD17B10LMNAAKR1B1 | |
| SCHEMBL28891144 | 0.80 | GABRA1 (0.42) | GABRA1GABRB1THRBTHRAHSD17B10 | |
| SCHEMBL670896 | 0.79 | MEN1 (0.44) | HSD17B10LMNAAKR1B1ALOX15ALOX12 | |
| SCHEMBL7062178 | 0.76 | TSHR (0.40) | GABRA1GABRB1THRBTHRAHSD17B10 | |
| SCHEMBL15709517 | 0.75 | PTGDR2 (0.39) | HSD17B10LMNAAKR1B1ALOX15ALOX12 | |
| SCHEMBL7067884 | 0.75 | THRB (0.40) | GABRA1GABRB1THRBTHRAHSD17B10 | |
| SCHEMBL1805856 | 0.74 | TSHR (0.44) | GABRA1GABRB1THRBTHRAMEN1 | |
| SCHEMBL7618929 | 0.74 | GABRA1 (0.41) | GABRA1GABRB1THRBTHRAHSD17B10 | |
| SCHEMBL1535013 | 0.74 | GABRA1 (0.37) | GABRA1GABRB1THRBTHRALMNA | |
| SCHEMBL4646137 | 0.74 | GABRA1 (0.41) | GABRA1GABRB1THRBTHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |