Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.90 |
| ▸ | EGFR | P00533 | 6/20 | 0.76 |
| ▸ | ABL1 | P00519 | 5/20 | 0.73 |
| ▸ | ABL2 | P42684 | 5/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | KIF5B | P33176 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107904 | 0.95 | SRC (1.00) | SRCEGFRABL1ABL2RET | |
| SCHEMBL28667953 | 0.94 | SRC (0.79) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL13020336 | 0.92 | SRC (0.76) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8098919 | 0.92 | SRC (0.90) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8098960 | 0.91 | SRC (0.90) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8098935 | 0.89 | SRC (0.90) | SRCEGFRABL1ABL2RET | |
| SCHEMBL30054291 | 0.89 | SRC (0.78) | SRCEGFRABL1ABL2RET | |
| SCHEMBL6462070 | 0.89 | SRC (0.78) | SRCEGFRABL1ABL2RET | |
| SCHEMBL20351767 | 0.88 | SRC (0.88) | SRCEGFRABL1ABL2 | |
| SCHEMBL7023465 | 0.87 | SRC (0.72) | SRCEGFRABL1ABL2RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |