Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PTGIR | P43119 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | CMA1 | P23946 | 1/20 | 0.56 |
| ▸ | CHKA | P35790 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586605 | 1.00 | SIGMAR1 (0.65) | SIGMAR1SMN1; SMN2GAAPTGIRTACR1 | |
| SCHEMBL3979749 | 0.94 | PTGIR (0.60) | SIGMAR1SMN1; SMN2GAAPTGIRTACR1 | |
| SCHEMBL9829472 | 0.90 | ABCB1 (0.57) | SIGMAR1SMN1; SMN2GAAPTGIRTACR1 | |
| SCHEMBL20804352 | 0.85 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKAPOLB | |
| SCHEMBL1043952 | 0.85 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKAPOLB | |
| SCHEMBL19285228 | 0.85 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKAPOLB | |
| SCHEMBL3714297 | 0.83 | SIGMAR1 (0.75) | SIGMAR1HRH3GSK3AGSK3B | |
| SCHEMBL12403963 | 0.83 | KMT2A (0.51) | SIGMAR1TACR1HRH3 | |
| SCHEMBL3171551 | 0.82 | PTGIR (0.81) | SIGMAR1SMN1; SMN2PTGIRHRH3CHKA | |
| SCHEMBL28048490 | 0.82 | PTGIR (0.75) | SIGMAR1SMN1; SMN2PTGIRHRH3CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056744-A1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043675-A1 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |