Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177800 | 0.83 | ROCK2 (0.42) | CNR1CNR2DRD2SLC6A4CYP3A4 | |
| SCHEMBL1177802 | 0.83 | ROCK2 (0.42) | CNR1CNR2DRD2SLC6A4CYP3A4 | |
| SCHEMBL13728399 | 0.79 | CYP11B2 (0.42) | CNR1CNR2DRD2SLC6A4ADRA2A | |
| Bromide SCHEMBL8108934 | 0.77 | HRH3 (0.37) | CYP11B2 | |
| SCHEMBL28442398 | 0.76 | TDP1 (0.41) | CNR1CNR2DRD2SLC6A4ADRA2A | |
| Cyclohexane SCHEMBL22288135 | 0.74 | TDP1 (0.44) | CNR1CNR2ADRA2AADRA2BADRA2C | |
| SCHEMBL11665783 | 0.74 | TDP1 (0.44) | CNR1CNR2ADRA2AADRA2BADRA2C | |
| Fumaric Acid SCHEMBL1177870 | 0.74 | KDM4E (0.41) | — | |
| SCHEMBL30735834 | 0.72 | HTR2C (0.49) | SLC6A2SLC6A3SLC6A4HTR2CHTR6 | |
| SCHEMBL7963921 | 0.72 | HTR2C (0.49) | SLC6A2SLC6A3SLC6A4HTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107307-A | PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0969005-A1 | Azabicyclic inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |