Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.61 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.50 |
| ▸ | CCNC | P24863 | 6/20 | 0.49 |
| ▸ | CDK8 | P49336 | 6/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MYLK | Q15746 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CILK1 | Q9UPZ9 | 1/20 | 0.49 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837335 | 0.86 | PRKCZ (0.59) | PRKCZSLC22A12ROCK2NAMPTMMP9 | |
| SCHEMBL12074301 | 0.83 | PRKCZ (0.73) | PRKCZROCK2NAMPTCYP11B1CYP11B2 | |
| SCHEMBL29501875 | 0.82 | PRKCZ (0.72) | PRKCZROCK2NAMPTCYP11B1CYP11B2 | |
| SCHEMBL6243938 | 0.82 | PRKCZ (0.72) | PRKCZROCK2NAMPTCYP11B1CYP11B2 | |
| SCHEMBL15733104 | 0.80 | ROCK2 (0.65) | PRKCZROCK2NAMPTMMP9CYP11B1 | |
| SCHEMBL5788498 | 0.80 | HDAC8 (0.68) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2774270 | 0.78 | PRKCZ (0.57) | PRKCZSLC22A12ROCK2NAMPTMMP9 | |
| SCHEMBL16502629 | 0.78 | SLC22A12 (0.54) | SLC22A12CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL12121434 | 0.77 | PRKCZ (0.56) | PRKCZMMP9CYP11B1CYP11B2ERN1 | |
| SCHEMBL2773031 | 0.77 | PRKCZ (0.65) | PRKCZROCK2NAMPTCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078726-A1 | IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |