SCHEMBL8108142

SCHEMBL8108142

CCCCc1cn(-c2c(C)cccc2C(=O)O)c(=O)n1Cc1ccc(-c2cnccc2-c2nnn[nH]2)cc1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 10/20 0.47
AGTR2 P50052 9/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8116081 0.98 AGTR1 (0.47) AGTR1AGTR2
SCHEMBL8120136 0.96 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL8122721 0.94 AGTR1 (0.47) AGTR1AGTR2
SCHEMBL8124160 0.94 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL8123267 0.93 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL8107183 0.93 AGTR1 (0.47) AGTR1AGTR2
SCHEMBL6498816 0.93 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL8108769 0.93 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL8116283 0.92 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL8116016 0.92 AGTR1 (0.47) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664802-B1 N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS SEARLE & CO (US) 2000-03-15 EP disclosed