Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120136 | 0.98 | AGTR1 (0.42) | AGTR1AGTR2PPARG | |
| SCHEMBL8116081 | 0.96 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8106957 | 0.94 | AGTR1 (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL8108142 | 0.94 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8122835 | 0.93 | AGTR1 (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL8109938 | 0.93 | PPARG (0.40) | AGTR1AGTR2PPARG | |
| SCHEMBL8117892 | 0.93 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8123999 | 0.92 | PPARG (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL8117608 | 0.92 | AGTR1 (0.42) | AGTR1AGTR2PPARG | |
| SCHEMBL6490941 | 0.92 | PPARG (0.46) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664802-B1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1994008990-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1994-04-28 | — | — | WO | disclosed |