Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13532701 | 0.91 | SIGMAR1 (0.44) | SIGMAR1HTR1ADRD2KDM4ECYP1A2 | |
| SCHEMBL13532676 | 0.87 | SIGMAR1 (0.56) | SIGMAR1HTR1ADRD2KDM4ECYP1A2 | |
| SCHEMBL13532685 | 0.87 | SIGMAR1 (0.41) | SIGMAR1HTR1ADRD2KDM4ECYP1A2 | |
| Lesopitron SCHEMBL246589 | 0.87 | HTR1A (0.52) | HTR1ADRD2CYP1A2HTR2A | |
| Lesopitron SCHEMBL9201343 | 0.86 | HTR1A (0.51) | HTR1ADRD2KDM4EHTR2A | |
| Lesopitron SCHEMBL1822413 | 0.86 | HTR1A (0.51) | HTR1ADRD2KDM4EHTR2A | |
| SCHEMBL8122288 | 0.81 | KIT (0.43) | SIGMAR1HTR1ADRD2KDM4EHTR2A | |
| SCHEMBL8417665 | 0.81 | SIGMAR1 (0.42) | SIGMAR1HTR1ADRD2KDM4ECYP1A2 | |
| SCHEMBL8416487 | 0.76 | KCNH2 (0.60) | SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL8418001 | 0.76 | SIGMAR1 (0.45) | SIGMAR1HTR1ADRD2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610140-B1 | 2-[4-(4-Azolylbutyl)-1-piperazinyl]-5-hydroxypyrimidin derivatives, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 2000-01-12 | — | — | EP | claimed |
| JP-6234762-A | — | — | None | — | — | JP | disclosed |
| EP-0610140-B1 | 2-[4-(4-Azolylbutyl)-1-piperazinyl]-5-hydroxypyrimidin derivatives, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 2000-01-12 | — | — | EP | disclosed |
| US-5444059-A | Anxiolytic agents | LABORATORIOS DEL. DR. ESTEVE, S.A. (ES) | 1995-08-22 | — | — | US | disclosed |
| JP-H06234762-A | 2-(4-(4-AZOLYLBUTYL)-1-PIPERAZINYL)-5-HYDROXYPYRIMIDINE DERIVATIVE | LAB DEL DR ESTEVE SA | 1994-08-23 | — | — | JP | disclosed |
| EP-0610140-A1 | 2- 4-(4-Azolylbutyl)-1-piperazinyl -5-hydroxypyrimidin derivatives, their preparation and their use als medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1994-08-10 | — | — | EP | disclosed |